Bangxing Hong, PhD
Assistant Professor, Department of Pathology
Georgia Cancer Center
Medical College of Georgia at Augusta University
The Hong laboratory is interested in developing novel immunotherapy through modulation of antigen presentation activity of dendritic cells, generation of antigen specific T cell-based cell therapy or developing oncolytic virus-based immunotherapy to target incurable tumor including glioblastoma, lymphoma, and other solid tumors.
The Bangxing Hong Lab
Health Sciences Campus
GCC - M. Bert Storey Research Building
1410 Laney Walker Blvd., CN-3112 Augusta, GA 30912
(706) 721-1187
State of the art technologies including CyTOF, scRNA-seq and proteomics are been used in our study. Ongoing projects include:
Modulation Antigen Presentation for Immunotherapy:
Through modulation the activities of antigen presentation attenuators (APAs), such as SOCS1 and A20, in antigen presentation cells (dendritic cells), we can reverse the tolerization of dendritic cells and generation of strong adaptive immune response again cancer (JITC 2023; Cancer Research 2009) or HIV(JCI 2011).
T cell Immunotherapy:
We develop antigen specific T cells including cytotoxic T lymphocytes (CTLs), Th9 or Tc9 cells to induce strong anti-tumor immune response against solid tumor through modulation of immune suppressive signaling in tumor microenvironment (Gene Therapy 2012; PNAS2014; JCI2011; JCI2012).
Oncolytic Virotherapy:
Oncolytic virotherapy is an emerging novel treatment for cancer patients. HSV-1-based oncolytic virus has been approved for metastatic cancer and relapse glioblastoma treatment. We are developing HSV-1 based oncolytic virus that disabling tumor-intrinsic and tumor-extrinsic factors that limit oncolytic virus infection, replication, and induction of anti-tumor immune response (JITC 2023; Clinical Cancer Research 2021).
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p38 MAPK in myeloma cells regulates osteoclast and osteoblast activity and induces bone destructionHe, J., Liu, Z., Zheng, Y., Qian, J., Li, H., Lu, Y., Xu, J., Hong, B., Zhang, M., Lin, P., Cai, Z., Orlowski, R. Z., Kwak, L. W., Yi, Q. & Yang, J., Dec 15 2012, In: Cancer Research. 72, 24, p. 6393-6402 10 p.Research output: Contribution to journal › Article › peer-review |
oHSV-P10 reduces glioma stem cell enrichment after oncolytic HSV therapySahu, U., Mullarkey, M. P., Pei, G., Zhao, Z., Hong, B. & Kaur, B., Jun 15 2023, In: Molecular Therapy Oncolytics. 29, p. 30-41 12 p.Research output: Contribution to journal › Article › peer-review |
esRAGE-expressing oHSV enhances anti-tumor efficacy by inhibition of endothelial cell activationSwanner, J., Shim, J. S., Rivera-Caraballo, K. A., Vázquez-Arreguín, K., Hong, B., Bueso-Perez, A. J., Lee, T. J., Banasavadi-Siddegowda, Y. K., Kaur, B. & Yoo, J. Y., Mar 16 2023, In: Molecular Therapy Oncolytics. 28, p. 171-181 11 p.Research output: Contribution to journal › Article › peer-review |
PKR induces TGF-β and limits oncolytic immune therapyHong, B., Sahu, U., Mullarkey, M. P., Hong, E., Pei, G., Yan, Y., Otani, Y., Banasavadi-Siddegowda, Y., Fan, H., Zhao, Z., Yu, J., Caligiuri, M. A. & Kaur, B., Feb 16 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006164.Research output: Contribution to journal › Article › peer-review |
Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cellsHong, B., Song, X. T., Rollins, L., Berry, L., Huang, X. F. & Chen, S. Y., Feb 1 2011, In: Journal of Clinical Investigation. 121, 2, p. 739-751 13 p.Research output: Contribution to journal › Article › peer-review |
Sequence analysis of 23S rRNA gene and its amplification in bacteria discriminative identificationHong, B. X., Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Mar 2004, In: Chinese Journal of Microbiology and Immunology. 24, 3, p. 241-244 4 p.Research output: Contribution to journal › Article › peer-review |
A20 plays a critical role in the immunoregulatory function of mesenchymal stem cellsDang, R. J., Yang, Y. M., Zhang, L., Cui, D. C., Hong, B., Li, P., Lin, Q., Wang, Y., Wang, Q. Y., Xiao, F., Mao, N., Wang, C., Jiang, X. X. & Wen, N., Aug 1 2016, In: Journal of Cellular and Molecular Medicine. 20, 8, p. 1550-1560 11 p.Research output: Contribution to journal › Article › peer-review |
Th9 cells promote antitumor immune responses in vivoLu, Y., Hong, S., Li, H., Park, J., Hong, B., Wang, L., Zheng, Y., Liu, Z., Xu, J., He, J., Yang, J., Qian, J. & Yi, Q., Nov 1 2012, In: Journal of Clinical Investigation. 122, 11, p. 4160-4171 12 p.Research output: Contribution to journal › Article › peer-review |
Application of oligonucleotide array technology for the rapid detection of pathogenic bacteria of foodborne infectionsHong, B. X., Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Sep 2004, In: Journal of Microbiological Methods. 58, 3, p. 403-411 9 p.Research output: Contribution to journal › Article › peer-review |
A Super TLR Agonist to Improve Efficacy of Dendritic Cell Vaccine in Induction of Anti-HCV ImmunityHong, B., Lee, S. H., Song, X. T., Jones, L., Machida, K., Huang, X. F. & Chen, S. Y., Nov 7 2012, In: PloS one. 7, 11, e48614.Research output: Contribution to journal › Article › peer-review |
A Th1-inducing adenoviral vaccine for boosting adoptively transferred T cellsSong, X. T., Turnis, M. E., Zhou, X., Zhu, W., Hong, B. X., Rollins, L., Rabinovich, B., Chen, S. Y., Rooney, C. M. & Gottschalk, S., Jan 2011, In: Molecular Therapy. 19, 1, p. 211-217 7 p.Research output: Contribution to journal › Article › peer-review |
Anti-β2M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicityZhang, M., Qian, J., Lan, Y., Lu, Y., Li, H., Hong, B., Zheng, Y., He, J., Yang, J. & Yi, Q., Sep 1 2014, In: International Journal of Cancer. 135, 5, p. 1132-1141 10 p.Research output: Contribution to journal › Article › peer-review |
P38 MAPK inhibits breast cancer metastasis through regulation of stromal expansionHong, B., Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J. T., Yang, J. & Yi, Q., Jan 1 2015, In: International Journal of Cancer. 136, 1, p. 34-43 10 p.Research output: Contribution to journal › Article › peer-review |
USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunityHong, B., Li, H., Lu, Y., Zhang, M., Zheng, Y., Qian, J. & Yi, Q., May 31 2014, In: Molecular cancer. 13, 1, 132.Research output: Contribution to journal › Article › peer-review |
Murine Th9 cells promote the survival of myeloid dendritic cells in cancer immunotherapyPark, J., Li, H., Zhang, M., Lu, Y., Hong, B., Zheng, Y., He, J., Yang, J., Qian, J. & Yi, Q., Aug 2014, In: Cancer Immunology, Immunotherapy. 63, 8, p. 835-845 11 p.Research output: Contribution to journal › Article › peer-review |
Efficacy of intracellular immune checkpoint-silenced DC vaccineWang, D., Huang, X. F., Hong, B., Song, X. T., Hu, L., Jiang, M., Zhang, B., Ning, H., Li, Y., Xu, C., Lou, X., Li, B., Yu, Z., Hu, J., Chen, J., Yang, F., Gao, H., Ding, G., Liao, L. & Rollins, L. & 3 others, , Feb 8 2018, In: JCI Insight. 3, 3Research output: Contribution to journal › Article › peer-review |
Bone marrow stromal cells derived MCP-1 reverses the inhibitory effects of multiple myeloma cells on osteoclastogenesis by upregulating the RANK expressionLiu, Z., Xu, J., Li, H., Zheng, Y., He, J., Liu, H., Zhong, Y., Lu, Y., Hong, B., Zhang, M., Lin, P., Du, J., Hou, J., Qian, J., Kwak, L. W., Yi, Q. & Yang, J., Dec 10 2013, In: PloS one. 8, 12, e82453.Research output: Contribution to journal › Article › peer-review |
A20 Controls Macrophage to Elicit Potent Cytotoxic CD4+ T Cell ResponseWang, L., Hong, B., Jiang, X., Jones, L., Chen, S. Y. & Huang, X. F., Nov 7 2012, In: PloS one. 7, 11, e48930.Research output: Contribution to journal › Article › peer-review |
Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte developmentHuang, X. F., Nandakumar, V., Tumurkhuu, G., Wang, T., Jiang, X., Hong, B., Jones, L., Won, H., Yoshii, H., Ozato, K., Masumi, A. & Chen, S. Y., 2016, In: Cell Death and Disease. 7, 6, e2260.Research output: Contribution to journal › Article › peer-review |
The expression of E gene region of dengue 2 virus in NIH3T3 and its identificationHong, B., Jiang, L. & Zhang, X., Sep 2000, In: Chinese Journal of Microbiology and Immunology. 20, 5, p. 477-480 4 p.Research output: Contribution to journal › Article › peer-review |
Generating CTLs against the subdominant EBV LMP antigens by transient expression of an A20 inhibitor with EBV LMP proteins in human DCsHong, B., Peng, G., Berry, L., Gottschalk, S., Jung, J. U., Chen, S. Y. & Huang, X. F., Aug 2012, In: Gene Therapy. 19, 8, p. 818-827 10 p.Research output: Contribution to journal › Article › peer-review |
Embryonic stem cells and mammary luminal progenitors directly sense and respond to microbial productsLee, S. H., Hong, B., Sharabi, A., Huang, X. F. & Chen, S. Y., Jul 2009, In: Stem Cells. 27, 7, p. 1604-1615 12 p.Research output: Contribution to journal › Article › peer-review |
Human suppressor of cytokine signaling 1 controls immunostimulatory activity of monocyte-derived dendritic cellsHong, B., Ren, W., Song, X. T., Evel-Kabler, K., Chen, S. Y. & Huang, X. F., Oct 15 2009, In: Cancer Research. 69, 20, p. 8076-8084 9 p.Research output: Contribution to journal › Article › peer-review |
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancersLu, Y., Hong, B., Li, H., Zheng, Y., Zhang, M., Wang, S., Qian, J. & Yi, Q., Feb 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2265-2270 6 p.Research output: Contribution to journal › Article › peer-review |
P38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppressionLu, Y., Zhang, M., Wang, S., Hong, B., Wang, Z., Li, H., Zheng, Y., Yang, J., Davis, R. E., Qian, J., Hou, J. & Yi, Q., Jun 24 2014, In: Nature communications. 5, 4229.Research output: Contribution to journal › Article › peer-review |
Oncolytic HSV therapy modulates vesicular trafficking inducing cisplatin sensitivity and antitumor immunityHong, B., Chapa, V., Saini, U., Modgil, P., Cohn, D. E., He, G., Siddik, Z. H., Sood, A. K., Yan, Y., Selvendiran, K., Pei, G., Zhao, Z., Yoo, J. Y. & Kaur, B., Jan 15 2021, In: Clinical Cancer Research. 27, 2, p. 542-553 12 p.Research output: Contribution to journal › Article › peer-review |
NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor ImmunotherapyOtani, Y., Yoo, J. Y., Lewis, C. T., Chao, S., Swanner, J., Shimizu, T., Kang, J. M., Murphy, S. A., Rivera-Caraballo, K., Hong, B., Glorioso, J. C., Nakashima, H., Lawler, S. E., Banasavadi-Siddegowda, Y., Heiss, J. D., Yan, Y., Pei, G., Caligiuri, M. A., Zhao, Z. & Antonio Chiocca, E. & 2 others, , Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1460-1473 14 p.Research output: Contribution to journal › Article › peer-review |
Suppression of HMGB1 Released in the Glioblastoma Tumor Microenvironment Reduces Tumoral EdemaHong, B., Muili, K., Bolyard, C., Russell, L., Lee, T. J., Banasavadi-Siddegowda, Y., Yoo, J. Y., Yan, Y., Ballester, L. Y., Bockhorst, K. H. & Kaur, B., Mar 29 2019, In: Molecular Therapy Oncolytics. 12, p. 93-102 10 p.Research output: Contribution to journal › Article › peer-review |
PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearanceRussell, L., Swanner, J., Jaime-Ramirez, A. C., Wang, Y., Sprague, A., Banasavadi-Siddegowda, Y., Yoo, J. Y., Sizemore, G. M., Kladney, R., Zhang, J., Lehman, N. L., Ostrowski, M. C., Hong, B., Caligiuri, M., Yu, J. & Kaur, B., Dec 1 2018, In: Nature communications. 9, 1, 5006.Research output: Contribution to journal › Article › peer-review |
Replication and Spread of Oncolytic Herpes Simplex Virus in Solid TumorsHong, B., Sahu, U., Mullarkey, M. P. & Kaur, B., Jan 2022, In: Viruses. 14, 1, 118.Research output: Contribution to journal › Review article › peer-review |
HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiformeArunachalam, E., Rogers, W., Simpson, G. R., Möller-Levet, C., Bolton, G., Ismael, M., Smith, C., Keegen, K., Bagwan, I., Brend, T., Short, S. C., Hong, B., Otani, Y., Kaur, B., Annels, N., Morgan, R. & Pandha, H., Dec 2022, In: BMC Cancer. 22, 1, 400.Research output: Contribution to journal › Article › peer-review |
Oncolytic HSV therapy increases trametinib access to brain tumors and sensitizes them in vivoYoo, J. Y., Swanner, J., Otani, Y., Nair, M., Park, F., Banasavadi-Siddegowda, Y., Liu, J., Jaime-Ramirez, A. C., Hong, B., Geng, F., Guo, D., Bystry, D., Phelphs, M., Quadri, H., Lee, T. J. & Kaur, B., Sep 6 2019, In: Neuro-Oncology. 21, 9, p. 1131-1140 10 p.Research output: Contribution to journal › Article › peer-review |
Meenaskhi Ahluwalisa, PhD
Konstantina Kyritsi, PhD
Jishi Ye, MD/PhD
Nobushige Tsuboi, PhD
