Alexander Verin - Research & Publications

Molecular mechanisms of lung injury and repair with focus on biochemical basis of pulmonary vascular cytoskeletal and permeability regulation.

* Structure and function of cytoskeletal proteins and protein phosphatases

* Phosphorylation/dephosphorylation as mechanism of vascular cytoskeletal regulation

* Relationship between pulmonary endothelial cell (EC) contractility/cytoskeleton and barrier function in vitro and in vivo

* Crosstalk between microtubules and microfilaments in EC barrier regulation

* Cytoskeletal responses to bioactive mediators and receptor/signal coupling in EC

* HDAC-mediated epigenetic mechanisms of lung injury

Verin's lab

Song L, Shi X, Kovacs L, Han W, John J, Barman SA, Dong Z, Lucas R, Fulton DJR, Verin AD, Su Y. Calpain Promotes LPS-induced Lung Endothelial Barrier Dysfunction via Cleavage of Talin. Am J Respir Cell Mol Biol. 2023 Dec;69(6):678-688. doi: 10.1165/rcmb.2023-0009OC. PubMed PMID: 37639326; PubMed Central PMCID: PMC10704117.

Patil RS, Kovacs-Kasa A, Gorshkov BA, Fulton DJR, Su Y, Batori RK, Verin AD. Serine/Threonine Protein Phosphatases 1 and 2A in Lung Endothelial Barrier Regulation. Biomedicines. 2023 Jun 5;11(6). doi: 10.3390/biomedicines11061638. Review. PubMed PMID: 37371733; PubMed Central PMCID: PMC10296329.

Ma Q, Yang Q, Xu J, Sellers HG, Brown ZL, Liu Z, Bordan Z, Shi X, Zhao D, Cai Y, Pareek V, Zhang C, Wu G, Dong Z, Verin AD, Gan L, Du Q, Benkovic SJ, Xu S, Asara JM, Ben-Sahra I, Barman S, Su Y, Fulton DJR, Huo Y. Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. Eur Heart J. 2023 Apr 7;44(14):1265-1279. doi: 10.1093/eurheartj/ehad044. PubMed PMID: 36721994; PubMed Central PMCID: PMC10319969.