The mission of the MCG Vision Discovery Institute is to engage in high impact research and discovery related to visual function and diseases, the outcome of which is expected to have far-reaching clinical applications for patients suffering from blindness and visual disorders.
Proposals are requested from MCG faculty whose projects will allow the VDI to achieve its mission. Preference is given to clinically-relevant projects that can be developed into larger extramurally-funded projects.
The following are research projects that have been funded for FY 2011-2012 Round 2
Investigators |
Project title |
| Mohammed Al-Shabrawey PhD, Ruth Caldwell PhD, Julian Nussbaum MD |
Role of Caspase-14 in Ischemic Retinopathy |
|
Azza El-Remessy PhD, Kathryn Bollinger MD, Alan Saul PhD |
Proinflammatory Role of TXNIP in optic neuropathy |
|
Zhiyong Yang PhD, Julian Nussbaum MD |
Combining Augmented Reality, Multisensory Enhancement, Visual Guidance, and Scene Description For Visual, Cognitive, and Behavioral Assistance and Rehabilitation For People With Low Vision |
The following are research projects that have been funded for FY 2011-2012
Investigators |
Project title |
|
Akinwuntan A., PhD., Espinosa D., M.D. and D'Amico M., EDD, OTR/L |
Driving-related low vision rehabilitation for individuals with age-related macular degeneration |
|
Caldwell R., PhD., Brooks S, M.D., Narayanan P, PhD,. Espinosa D, M.d. and Yancey L, M.D. |
Mechanisms of neurovascular injury; role of Arginase 2 |
|
Hegde J., PhD. and Nussbaum J., M.D. |
Functional characterization of 3-D vision faculties in patient with age-related macular degeneration |
|
Liou G., PhD., Espinosa D., M.D. and Caldwell R, PhD. |
Mechanism of adenosine signaling dysfunction in diabetic retinopathy |
|
Martin P., PhD. and Pace B., M.D. |
Preclinical testing of MMF/DMF (Fumaderm), a novel inducer of fetal hemoglobin (HbF) production in a humanized mouse model of sickle cell disease: relevance to treatment/prevention of sickle cell retinopathy |
|
Mumm J., PhD. and Gupta P., M.D. |
Corneal confocal microscopy in zebrafish: a model for diabetes induced neuropathy |
|
Saul A., PhD. and Bogorad D., M.D. |
Improving electroretinography |
The following are research projects that have been funded for FY 2010-2011
Investigators |
Project title |
| Caldwell, R. B., PhD., and Brooks, S., MD | Hyperoxia therapy for ischemic retinopathy |
| Saul, A., PhD., Mumm, J., PhD., and Bogorad, D., MD | Development of novel electroretinographic techniques |
| El-Remessy, A., PhD., Bollinger, K., M.D., PhD. and Prosser, A., M.D. | Thioredoxin interacting protein (TXNIP) is a neuroglial inflammatory mediator in Glaucoma and models of optic neuropathy |
| Liou, G., PhD., Saul, A. PhD., and Fatteh, N., M.D. | Development of New Anti-Inflammatory Therapies for Diabetic Retinopathy |
| Mumm, J., PhD., Nussbaum, J., M.D. and Rempala, G., PhD. | Genetic Circuitry of Cell-Specific Retinal Neuron Regeneration |
| Bollinger, K., M.D., PhD., Bogorad, D., M.D., Looney, S., PhD., Mills, J., M.D., and Ulrich, L., M.D. | Assessing Susceptibility to POAG with Proteomic Biomarkers from Aqueous Humor |
| Bradley, K, EDD, OTR/L, FAOTA and Yang, Z. PhD. | The Relationship between 2-Dimensional and 3-Dimensional Visual Scanning and Performances in Safe, Daily Living and Environmental Performances: A Correlation Study among Adult Subjects with Vision Impairments. |
| Ganapathy, V., PhD., Nussbaum, J., M.D., and Patterson, E., M.D. | Prevalence of HFE mutation (C282Y) in AMD |
| Hegde, J., PhD. and Odel, J., M.D. | Using the Neuroscientific Principles of Ambiguity Reduction to the Rehabilitative Treatment of Optic Neuropathies and Cerebral Visual Disorders |
| Martin, P., PhD., and Nussbaum, J., M.D. | Analysis of GPR109A, a Novel Anti-Inflammatory Drug Target in RPE |
| Gupta, P., M.D. and El-Remessy, A., PhD. | Role of Nerve Growth Factor in the Development of Keratitis and Dry Eye |
| Baban, Babak, PhD., MBA, Caldwell, R., PhD. and Gupta, P., M.D. | Modulation of Indoleamine2.3 dioxygenase (IDO) in experimental uveitis: A potential novel therapeutic approach |
| Al-Shabrawey, M., PhD. and Nussbaum, J., M.D. | 12-Lipoxyegnase pathway of arachidonic acide metabolism in diabetic retinopathy |
The following are research projects that were funded for 2009 - 2010
Investigators |
Project title |
| Bollag, W. PhD., Gupta, P., MD and Bollag, R., MD, PhD. | The corneal epithelium phospholipase D2/Aquaporin-3 signaling module in eye disease |
| Bartoli, M., PhD., Mammen, A., MD, and Yee, K., MD | Validation of the neuroimmune regulatory protein CD47 as an immunological biomarker of diabetic retinopathy |
| Liou, G., PhD., Khan, S., MD and Caldwell, R. B., PhD. | Development of new anti-inflammatory therapies for diabetic retinopathy |
| Caldwell, R. B., PhD., and Brooks, S., MD |
Regulation of retinal angiogenesis - Role of oxygen in promoting normal vascular growth and preventing vitreous neovascularization in ischemic retinopathy |
| Saul, A., PhD., Mumm, J., PhD., and Bogorad, D., MD | Development of novel electroretinographic techniques |
| Ganapathy, V., PhD., Nussbaum, J.,MD and Patterson, E., MD | Prevalence of HFE mutation in age-related macular degeneration |
| Hegde, J., PhD., and Odel, J., MD | Using the neuroscientific principles of ambiguity reduction to the rehabilitative treatment of optic neuropathies and cerebral visual disorders |
| Yang, Z., PhD., and Bradley, K., EdD, and Cosper, S., MS | Applications of a statistical theory of vision to vision rehabilitation |
