Ravindra Kolhe, MD, PhD, a molecular pathologist and director of the Georgia Esoteric and Molecular Laboratory at the Medical College of Georgia, chairs the medical school’s Department of Pathology. He also serves as Edgar R. Pund, MD, Distinguished Chair in Pathology.
Kolhe first came to MCG in 2007 as a postdoctoral fellow, focused on cancer epigenetics and therapeutics at the Georgia Cancer Center. He went on to complete his residency in anatomic and clinical pathology at MCG and Wellstar MCG Health in 2012, before joining the medical school’s faculty later that year.
He was recruited to MCG to help spearhead the development of the Georgia Esoteric and Molecular (GEM) Pathology Laboratory, which provides diagnostic services for the diagnosis and comprehensive evaluation of disease, primarily through the molecular analysis of tissues and cells. Under his leadership, the lab has developed multiple new Clinical Laboratory Improvement Amendments (CLIA)-certified assays and platforms that have helped improve both diagnostic efforts and clinical trials. The GEM Lab team has pioneered diagnostic tools that have reshaped the field of molecular pathology by integrating cutting-edge technologies like optical genome mapping, an unprecedented, high-resolution look for all structural genetic variants that are known to cause cancer, in clinical labs.
Under Kolhe’s leadership, the GEM Lab has become the gold standard among academic molecular labs, earning recognition as an NCI-MATCH laboratory for precision medicine cancer trials. Kolhe is also working closely with Georgia Cancer Center Director Jorge Cortes, MD, to establish a Center for Cancer Genomics at MCG, which would serve as a central hub for cancer-related genomics.
In March 2020, in the early days of the COVID-19 pandemic in Georgia, the GEM Lab swiftly developed and validated a PCR-based COVID-19 test to detect genetic material from the novel coronavirus. It was one of the first programs to have this critical test in the Southeast. The team worked quickly to expand testing across the health system and became an invaluable resource for the entire state. Kolhe was appointed lead pathologist on Georgia Governor Brian Kemp’s Taskforce for COVID-19, charged with overseeing crucial parts of testing, including laboratory methods, data management, logistics and supplies, as well as spearheading new technology and testing innovations. During his tenure on the task force, the GEM Lab completed a comprehensive assessment of COVID-19 testing resources, helping secure budget allocations, quickly implementing high-throughput COVID-19 testing systems in four other CLIA-certified labs and, in turn, greatly enhancing testing capacity for the State of Georgia.
Kolhe’s experience on the task force was also pivotal in helping him secure funding from the Centers for Disease Control and Prevention to establish the Georgia Pathogen Genomic Center of Excellence and the Center for Applied Pathogen Epidemiology and Outbreak Response (CAPE). This initiative, a collaboration led by the Georgia Department of Public Health and four other academic centers in Georgia, is part of the CDC’s $90 million investment to establish five networks of centers across the country. Kolhe and his team will be critical to preparing the state for the next pandemic by helping develop testing methods, as well as testing new technology and applications and validating the results they provide. They also will work to train, and retain, a reserve workforce of qualified laboratory personnel, develop a network of clinical laboratories and create an interphase between those labs and public health, ensuring that important data reaches the people it needs to rapidly, completely and accurately.
In addition to his role as interim chair, he has also served as the medical school’s associate dean for translational research, associate director for genomics at the Georgia Cancer Center, and clinical service chief for pediatric and adult clinical pathology at Wellstar MCG Health.
MORE ABOUT DR. KOLHE
