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- Using a humanized mouse model to predict which potential living donor is immunologically the best match for a prospective living donor kidney transplant recipient.
Clinical Trial
Using a humanized mouse model to predict which potential living donor is immunologically the best match for a prospective living donor kidney transplant recipient.
The purpose of this study is to determine the best immunologic match between potential living donors and their recipients. We will create a mouse with the exact immunologic makeup of the potential living kidney transplant recipient. We will replicate these mice so we have as many mice as the potential recipient has living donors. We will take blood from each potential living donor and inject peripheral blood mononuclear cells (PBMCs) into the recipient?s mouse model. We will use genomic, proteomic and immunological signatures of human allograft rejection (foreign transplantation antigens, allogeneic recognition) established in our laboratory as well as immunobiological signatures of acceptance of the transplant (self-antigens, autologous, and combination), which also will be established in our laboratory to determine the optimal living-donor for the kidney transplant recipient.
Eligibility Criteria
- List the inclusion/exclusion criteria: 1. Subjects between 18-70 years of age 2. Subject has to qualify for a living donor renal transplant and has to have potential living kidney donors to be tested. 3. Subjects must have the ability to sign written informed consent. Exclusion Criteria: 1. Subjects with significant uncontrolled illnesses.