Chemistry & Biochemistry

The Verbeck Laboratory

Guido Verbeck, PhD

Guido Verbeck, PhD

Department Chair, Chemistry and Biochemistry

Professor, Chemistry

Research Summary

Dr. Guido F. Verbeck, Professor of Chemistry and Biochemistry, is an expert is mass spectrometry, specifically instrument design and development.  Dr. Verbeck received his PhD as a Proctor & Gamble fellow in chemistry at Texas A&M University. Dr. Verbeck has developed mass spectrometers and chemical instruments over the past 23 years, and has been a member of the analytical community for 27 years. His appointment is at the Augusta University where he continues to design novel ion optical devices for miniaturization, preparative, and analytical mass spectrometry, and is the Director for the Laboratory of Imaging Mass Spectrometry.  In this appointment Dr. Verbeck has received $5M in external funding, 90 peer reviewed publications, 15 awarded patents and 12 applications, and graduated 26 graduate students in instrument development.  He is currently an editor with the Journal of Analytical Oncology and the Journal of the Society for Mass Spectrometry. Dr. Guido Verbeck continues to develop new mass spectrometers specifically for single-cell analysis for cancer biomarkers, nanoparticle development for pharmaceutical and toxicological biochemical effects, and determining the biological mechanisms for biomolecular condensates.  

Contact Us

The Verbeck Lab

Health Sciences Campus

Science & Mathematics Building

706-667-4148

gverbeck@augusta.edu

 

Research Interests

The focus of the Verbeck Lab is on discovery and mitigation of unique research needs, to aid the researcher in forwarding their programs. The lab has a student-centered approach, where 2 training courses are conducted a year, and analyses are performed by the student. We offer a suite of mass spectrometry and imaging instruments with applications in chemistry, biochemistry, toxicology, environmental, forensic, and material science.

The following support equipment is found within Dr. Verbeck’s laboratories, the Laboratory for Imaging Mass Spectrometry, and will be accessible for this project, GE-4040 BC.

Microscopy

  • Cellular Bioworkstation, which includes, Nikon Eclipse TE2000 Inverted microscope, Horiba iHR550 735nm Raman System confocal imaging, Spectra Physics 30fsec 800nm Laser for cell breaching, Fluorescent Microscopy, and Imaging Stage.
  • Nikon AZ100 Stereoscope with 2x, and 5x long working distance objectives with Bright Field, and Fluorescence microscopy.
  • Nikon E100 with AmScope MU Camera, 10x, 20x, 40x

Mass Spectrometry

  • Thermo LTQ – Orbitrap, with MALDI and LDI sources.
  • Waters, Xevo APGC – Triple Quadrupole Mass Spectrometer with Agilent 7890 Gas Chromatography.
  • Thermo LTQ, Ion Trap Mass Spectrometer with direct-inject Electro- and Nanospray sources.
  • Thermo TSQ, with direct inject Electro- and Nanospray sources. Paperspray autosampler and multiplate reader.
  • 2 x Applied Biosystems MDS Scix 4000 QTrap mass spectrometers for direct liquid inject using electrospray or nanospray ionization.

Spectroscopy

  • Thermo/Nicolet iS10 Infrared Spectrometer with Attenuated Total Reflection and Transmission cells.
  • Horiba - iHR550 Raman Spectrometer

 

 

Selected Publications

  • Reyes, K.; Verbeck, G.F., “True One Cell Chemical Analysis in Cancer Research: A Review”, J. Anal. Oncology, 12 (2023) 37-52.

 

  • Thomas, B.; Anderson, K.; W. De Silva, I.; Verbeck, G.; Taylor, S., “ATR-FTIR Spectroscopy is Sensitive to Thermal Decay of Bone Collagen”, App. Spect.,77 (2023) 53.

 

  • Smart, K.: Reyes, K.; Wilder, K., Acree, W.; Verbeck, G.; Golden, T., “Ionic liquids as stationary phases for the gas chromatographic separation of fentanyl analogues”, For. Chem. 31 (2022) 100452.

 

  • Nayek, S.; Lund, A.K., Verbeck, G.F., “Inhalation exposure to silver nanoparticles induces hepatic inflammation and oxidative stress, associated with altered renin-angiotensin system signaling, in Wistar rats”, Envirom. Tox, 37 (2022) 457-467.

 

  • Virgen, C. A.; Fox, J.D.; Santariello, P.; Winfield, J.L.; Wright, K.C.; Verbeck, G.F., “Portable membrane inlet mass spectrometric detection and analysis of chemical warfare agent simulants at the U.S. Army Dugway Proving Ground S/K Challenge event” , Int. J. Mass Spectrom. Invited, 468 (2021) 116635.

 

  • Subedi, D.R.; Jang, Y.; Ganesan, A.; Schoellhorn, S.; Reid, R.l Verbeck, G.F.; D’Souza, F., “Donor–acceptor conjugates derived from cobalt porphyrin and fullerene via metal-ligand axial coordination: Formation and excited state charge separation”, J. Porphyrins Phthalocyanines, 25 (2021) 533-546.

 

  • De Silva, I.W.; Couch, A.; Verbeck, G.F., “Paper spray mass spectrometry utilized with synthetic microporous polyolefin silica matrix substrate in rapid detection and identification of more than 190 synthetic fentanyl analogs”, J. Am. Soc. Mass Spectrom, 32 (2021) 420-428.