Research in Biological Sciences

Research in the biological sciences gives students a broader appreciation for their field of study. Research is an excellent way to develop problem-solving and creative thinking skills. In the process, students benefit from increased interactions with fellow students and faculty while they gain confidence through hands-on, real-world experiences in the field and in the lab.

AU Students have the opportunity to present their findings on campus and at regional and national meetings. Meetings include the Georgia Academy of Sciences Conference, the Association of Southeastern Biologists (ASB) Meeting, the Southeastern Estuarine Research Society (SEERS) Meeting, and the Southeastern Regional Yeast Meeting (SERYM), among others. In addition, the Augusta University chapter of Phi Kappa Phi hosts an annual, campus-wide research conference where students present their findings in poster format and oral presentations to the Augusta community.

Throughout the year, the Center for Undergraduate Research and Scholarship hosts the Brown Bag Series where Augusta University students from all disciplines present their research.

Contact Us

Biological Sciences

Health Sciences Campus

Science & Mathematics Building

706-737-1539

biology@augusta.edu

The Goldstein Lab

The Goldstein Lab the pathogenesis and repair of diffuse white matter injury – the most common neuropathological outcome of premature birth.

Research Interests: Brain Injury / Myelin / Epigenetics /

Creativity, Discovery, Engagement

Publications

Publication
Amino acid restriction, aging, and longevity: an update Austad, S. N., Smith, J. R. & Hoffman, J. M., 2024, In: Frontiers in Aging. 5, 1393216. Research output: Contribution to journal › Review article › peer-review
The companion dog as a model for inflammaging: a cross-sectional pilot study Dog Aging Project Consortium, Dec 2024, In: GeroScience. 46, 6, p. 5395-5407 13 p. Research output: Contribution to journal › Article › peer-review
Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study Ditzler, B., Evans, J. B., Illing, K., Kaeberlein, M., Promislow, D. E. L., Brindle, E., Hoffman, J. M. & Creevy, K. E., May 2024, In: American Journal of Veterinary Research. 85, 5, p. 1-7 7 p. Research output: Contribution to journal › Article › peer-review
THE BENEFITS OF A PHYSICAL THERAPY PROGRAM AMONG BREAST CANCER PATIENTS WHO HAVE UNDERGONE A MASTECTOMY Asbury, E., Bennett, H., Cannon, J. & Kindred, M., 2024, In: Journal of Cancer Rehabilitation. 7, 2, p. 80-92 13 p. Research output: Contribution to journal › Article › peer-review
Absence of MMF1 disrupts heme biosynthesis by targeting Hem1pin Saccharomyces cerevisiae Whitaker, G. H., Ernst, D. C. & Downs, D. M., Dec 2021, In: Yeast. 38, 12, p. 615-624 10 p. Research output: Contribution to journal › Article › peer-review
Analysis of 2,570 responses to Dog Aging Project End of Life Survey demonstrates that euthanasia is associated with cause of death but not age Dog Aging Project Consortium, Feb 2024, In: Journal of the American Veterinary Medical Association. 262, 2, p. 1-10 10 p. Research output: Contribution to journal › Article › peer-review
Gut Microbiome Transplants and Their Health Impacts across Species Levine, B. H. & Hoffman, J. M., Jun 2023, In: Microorganisms. 11, 6, 1488. Research output: Contribution to journal › Review article › peer-review
Lactating SKH-1 furless mice prioritize own comfort over growth of their pups Hoffman, J. M., Schmitz, B., Pfabe, J. U., Ohrnberger, S. A. & Valencak, T. G., Aug 2023, In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 193, 4, p. 453-459 7 p. Research output: Contribution to journal › Article › peer-review
Blockade of interleukin-6 trans-signaling prevents mitochondrial dysfunction and cellular senescence in retinal endothelial cells Hoffman, J. M., Robinson, R., Greenway, G., Glass, J., Budkin, S. & Sharma, S., Dec 2023, In: Experimental eye research. 237, 109721. Research output: Contribution to journal › Article › peer-review
Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques Stout, M. B., Vaughan, K. L., Isola, J. V. V., Mann, S. N., Wellman, B., Hoffman, J. M., Porter, H. L., Freeman, W. M. & Mattison, J. A., Aug 2023, In: GeroScience. 45, 4, p. 2337-2349 13 p. Research output: Contribution to journal › Article › peer-review
Production of a p65^fl/fl/LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages Korkaya, A. K., Fischer, J., Peppers, A., Crosson, S. M., Rayamajhi, M., Miao, E. A., Baldwin, A. S. & Bradford, J. W., Nov 2023, In: Innate Immunity. 29, 8, p. 171-185 15 p. Research output: Contribution to journal › Article › peer-review
Orchiectomy sensitizes cortical bone in male mice to the harmful effects of kynurenine Bensreti, H., Yu, K., Alhamad, D. W., Shaver, J., Kaiser, H., Zhong, R., Whichard, W. C., Parker, E., Grater, L., Faith, H., Johnson, M., Cooley, M. A., Fulzele, S., Hill, W. D., Isales, C. M., Hamrick, M. W. & McGee-Lawrence, M. E., Aug 2023, In: Bone. 173, 116811. Research output: Contribution to journal › Article › peer-review
Cyclic Nucleotides as Mediators of Acinar and Ductal Function Albers, T. & Sabbatini, M. E., 2021, Cyclic Nucleotides as Mediators of Acinar and Ductal Function. Pancreapedia Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Validation of a Carbohydrate Antigen-19-9 Enzyme-Linked Immunosorbent Assay Kit Using a Mouse Model of Pancreatic Cancer Mondal, S. & Sabbatini, M., 2021, In: The Arsenal: The Undergraduate Research Journal of Augusta University. 4, 1, p. 27-27 1 p. Research output: Contribution to journal › Article › peer-review
Characterizing the NADPH Oxidase 1-Evoked Pancreatic Stellate Cell Secretome Chakraborty, A., Souravi, M., Zhi, W., Csanyi, G. & Sabbatini, M., 2021, In: The Arsenal: The Undergraduate Research Journal of Augusta University. 4, 1, p. 6-6 1 p. Research output: Contribution to journal › Article › peer-review
Targeting tumor microenvironment-associated cells to reverse therapy resistance Piranlioglu, R., Bradford, J. W. & Arbab, A. S., Jan 1 2021, New Targeting in the Reversal of Resistant Glioblastomas. Elsevier, p. 115-144 30 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter
Sulforaphane has an additive anticancer effect to FOLFOX in highly metastatic human colon carcinoma cells Čižauskaitė, A., Šimčikas, D., Schultze, D., Kallifatidis, G., Bruns, H., Čekauskas, A., Herr, I., Baušys, A., Strupas, K. & Schemmer, P., Nov 2022, In: Oncology Reports. 48, 5, 205. Research output: Contribution to journal › Article › peer-review
A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus Hoffman, J. M., Tran, V. L., Wachtman, L. M., Green, C. L., Jones, D. P. & Promislow, D. E. L., Apr 1 2016, In: Experimental Gerontology. 76, p. 17-24 8 p. Research output: Contribution to journal › Article › peer-review
Invariance and plasticity in the Drosophila melanogaster metabolomic network in response to temperature Hariharan, R., Hoffman, J. M., Thomas, A. S., Soltow, Q. A., Jones, D. P. & Promislow, D. E. L., Dec 24 2014, In: BMC Systems Biology. 8, 1, 139. Research output: Contribution to journal › Article › peer-review
Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster Hoffman, J. M., Soltow, Q. A., Li, S., Sidik, A., Jones, D. P. & Promislow, D. E. L., Aug 2014, In: Aging Cell. 13, 4, p. 596-604 9 p. Research output: Contribution to journal › Article › peer-review
Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality within North American veterinary teaching hospitals Hoffman, J. M., Lourenço, B. N., Promislow, D. E. L. & Creevy, K. E., Nov 2018, In: Journal of Small Animal Practice. 59, 11, p. 681-690 10 p. Research output: Contribution to journal › Article › peer-review
Reproductive Capability Is Associated with Lifespan and Cause of Death in Companion Dogs Hoffman, J. M., Creevy, K. E. & Promislow, D. E. L., Apr 17 2013, In: PloS one. 8, 4, e61082. Research output: Contribution to journal › Article › peer-review
The companion dog as a model for the longevity dividend Creevy, K. E., Austad, S. N., Hoffman, J. M., O’Neill, D. G. & Promislow, D. E. L., Jan 2016, In: Cold Spring Harbor perspectives in medicine. 6, 1 Research output: Contribution to journal › Article › peer-review
MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1b deficiency Parker, E., Mendhe, B., Ruan, L., Marshall, B., Zhi, W., Liu, Y., Fulzele, S., Tang, Y. L., McGee-Lawrence, M., Lee, T. J., Sharma, A. K., Johnson, M., Chen, J. & Hamrick, M. W., Aug 2022, In: Physiological Genomics. 54, 8, p. 296-304 9 p. Research output: Contribution to journal › Article › peer-review
Development of a novel purification protocol to isolate and identify brain microglia Doughty, D., Rajpurohit, S. K., Trang, A., Alptekin, A., Korkaya, A. K., Achyut, B. R., Arbab, A. S. & Bradford, J. W., Aug 2022, In: Experimental Biology and Medicine. 247, 16, p. 1433-1446 14 p. Research output: Contribution to journal › Article › peer-review
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model Yang, L., Wu, C., Parker, E., Li, Y., Dong, Y., Tucker, L., Brann, D. W., Lin, H. W. & Zhang, Q., 2022, In: Theranostics. 12, 5, p. 2205-2231 27 p. Research output: Contribution to journal › Article › peer-review
Long Non-coding RNA MALAT1 Is Depleted With Age in Skeletal Muscle in vivo and MALAT1 Silencing Increases Expression of TGF-β1 in vitro Ruan, L., Mendhe, B., Parker, E., Kent, A., Isales, C. M., Hill, W. D., McGee-Lawrence, M., Fulzele, S. & Hamrick, M. W., Jan 21 2022, In: Frontiers in Physiology. 12, 742004. Research output: Contribution to journal › Article › peer-review
Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy Parker, E., Khayrullin, A., Kent, A., Mendhe, B., Youssef El Baradie, K. B., Yu, K., Pihkala, J., Liu, Y., McGee-Lawrence, M., Johnson, M., Chen, J. & Hamrick, M., Jan 3 2022, In: Frontiers in Cell and Developmental Biology. 9, 790437. Research output: Contribution to journal › Article › peer-review
The Glucocorticoid Receptor in Osterix-Expressing Cells Regulates Bone Mass, Bone Marrow Adipose Tissue, and Systemic Metabolism in Female Mice During Aging Pierce, J. L., Sharma, A. K., Roberts, R. L., Yu, K., Irsik, D. L., Choudhary, V., Dorn, J. S., Bensreti, H., Benson, R. D., Kaiser, H., Khayrullin, A., Davis, C., Wehrle, C. J., Johnson, M. H., Bollag, W. B., Hamrick, M. W., Shi, X., Isales, C. M. & McGee-Lawrence, M. E., Feb 2022, In: Journal of Bone and Mineral Research. 37, 2, p. 285-302 18 p. Research output: Contribution to journal › Article › peer-review
Tachycardia evoked from insular stroke in rats is dependent on glutamatergic neurotransmission in the dorsomedial hypothalamus Marins, F. R., Limborço-Filho, M., Iddings, J. A., Xavier, C. H., Biancardi, V. C., Stern, J. E., Ramiro Diaz, J., Oppenheimer, S. M., Filosa, J. A. & Peliky Fontes, M. A., Nov 2021, In: European Journal of Neurology. 28, 11, p. 3640-3649 10 p. Research output: Contribution to journal › Article › peer-review
Mitochondrial DNA Haplotype Diversity in Two Portunid Populations Found along the Georgia and South Carolina Coasts Abdulovic-Cui, A., Mannix, S., Coleman, A., White, B., Mingledolph, K. & Reichmuth, J. M., May 1 2021, In: Southeastern Naturalist. 20, 2, p. 367-376 10 p. Research output: Contribution to journal › Article › peer-review
Arrb1 regulates metabolic reprogramming to promote glycolysis in stem cell-like bladder cancer cells Mamouni, K., Kim, J., Lokeshwar, B. L. & Kallifatidis, G., Apr 2 2021, In: Cancers. 13, 8, 1809. Research output: Contribution to journal › Article › peer-review
Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells Al-Shabrawey, M., Hussein, K., Wang, F., Wan, M., Elmasry, K., Elsherbiny, N., Saleh, H., Yu, P. B., Tawfik, A. & Ibrahim, A. S., Jan 29 2021, In: Frontiers in immunology. 11, 568795. Research output: Contribution to journal › Article › peer-review
Role of fibro-adipogenic progenitor cells in muscle atrophy and musculoskeletal diseases Parker, E. & Hamrick, M. W., Jun 2021, In: Current Opinion in Pharmacology. 58, p. 1-7 7 p. Research output: Contribution to journal › Review article › peer-review
Targeting mitochondrial metabolism in prostate cancer with triterpenoids Mamouni, K., Kallifatidis, G. & Lokeshwar, B. L., Mar 1 2021, In: International journal of molecular sciences. 22, 5, p. 1-15 15 p., 2466. Research output: Contribution to journal › Review article › peer-review
The role of β-arrestins in regulating stem cell phenotypes in normal and tumorigenic cells Kallifatidis, G., Mamouni, K. & Lokeshwar, B. L., Dec 1 2020, In: International journal of molecular sciences. 21, 23, p. 1-16 16 p., 9310. Research output: Contribution to journal › Review article › peer-review
Decreased parenchymal arteriolar tone uncouples vessel-to-neuronal communication in a mouse model of vascular cognitive impairment Kim, K. J., Diaz, J. R., Presa, J. L., Muller, P. R., Brands, M. W., Khan, M. B., Hess, D. C., Althammer, F., Stern, J. E. & Filosa, J. A., Jun 2021, In: GeroScience. 43, 3, p. 1405-1422 18 p. Research output: Contribution to journal › Article › peer-review
A novel heme transporter from the energy coupling factor family is vital for group a streptococcus colonization and infections Chatterjee, N., Cook, L. C. C., Lyles, K. V., Nguyen, H. A. T., Devlin, D. J., Thomas, L. S. & Eichenbaum, Z., Jul 1 2020, In: Journal of Bacteriology. 202, 14, e00205-20. Research output: Contribution to journal › Article › peer-review
Transcriptomic analysis of streptococcus pyogenes colonizing the vaginal mucosa identifies hupy, an MtsR-regulated adhesin involved in heme utilization Cook, L. C. C., Chatterjee, N., Li, Y., Andrade, J., Federle, M. J. & Eichenbaum, Z., May 1 2019, In: mBio. 10, 3, e00848-19. Research output: Contribution to journal › Article › peer-review
Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases Gómez-Contreras, P., Ramiro-Díaz, J. M., Sierra, A., Stipp, C., Domann, F. E., Weigel, R. J. & Lal, G., Jan 1 2017, In: Clinical and Experimental Metastasis. 34, 1, p. 37-49 13 p. Research output: Contribution to journal › Article › peer-review
Atypical chemokine receptors in tumor cell growth and metastasis Lokeshwar, B. L., Kallifatidis, G. & Hoy, J. J., 2020, GPCR Signaling in Cancer. Academic Press Inc., p. 1-27 27 p. (Advances in Cancer Research; vol. 145). Research output: Chapter in Book/Report/Conference proceeding › Chapter
NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis Xia, D., Halder, B., Godoy, C., Chakraborty, A., Singla, B., Thomas, E., Shuja, J. B., Kashif, H., Miller, L., Csanyi, G. & Sabbatini, M. E., Feb 1 2020, In: Free Radical Biology and Medicine. 147, p. 139-149 11 p. Research output: Contribution to journal › Article › peer-review
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In: Experimental Gerontology. 130, 110797. Research output: Contribution to journal › Review article › peer-review
Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In: Experimental Gerontology. 130, 110818. Research output: Contribution to journal › Article › peer-review
Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin Folk, W. P., Kumari, A., Iwasaki, T., Pyndiah, S., Johnson, J. C., Cassimere, E. K., Abdulovic-Cui, A. L. & Sakamuro, D., Apr 5 2019, In: Journal of Biological Chemistry. 294, 14, p. 5700-5719 20 p. Research output: Contribution to journal › Article › peer-review
A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation Jung, E., Griner, R. D., Mann-Blakeney, R. & Bollag, W. B., 1998, Journal of Investigative Dermatology. 4 ed. Nature Publishing Group, Vol. 110. p. 318-323 6 p. Research output: Chapter in Book/Report/Conference proceeding › Chapter
Augmented astrocyte microdomain Ca ²⁺ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice Diaz, J. R., Kim, K. J., Brands, M. W. & Filosa, J. A., Mar 2019, In: Glia. 67, 3, p. 551-565 15 p. Research output: Contribution to journal › Article › peer-review
Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment Rausch, V., Liu, L., Apel, A., Rettig, T., Gladkich, J., Labsch, S., Kallifatidis, G., Kaczorowski, A., Groth, A., Gross, W., Gebhard, M. M., Schemmer, P., Werner, J., Salnikov, A. V., Zentgraf, H., Büchler, M. W. & Herr, I., Jul 2012, In: Journal of Pathology. 227, 3, p. 325-335 11 p. Research output: Contribution to journal › Article › peer-review
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation Salazar, N., Muñoz, D., Kallifatidis, G., Singh, R. K., Jordà, M. & Lokeshwar, B. L., Aug 28 2014, In: Molecular cancer. 13, 1, 198. Research output: Contribution to journal › Article › peer-review
Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B. M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G., Altevogt, P., Wirth, T., Werner, J., Schemmer, P., Büchler, M. W., Salnikov, A. V. & Herr, I., Jul 2009, In: Gut. 58, 7, p. 949-963 15 p. Research output: Contribution to journal › Article › peer-review

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Research News

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AU undergraduate research team selected to participate in national program

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STAR Program opens research pathways for undergrads

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Physics faculty publishes article in Nature family of journals

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